Investigating the role of perineuronal nets as a non-cellular mechanism of emotion and mood
Emotions and mood have a bidirectional influence with our physiology, behaviour, cognition, and immune system.
Hence mood disorders such as depression are debilitating and co-exist with other diseases. On the other hand, positive mood states are linked to well-being and increased immune response.
Understanding the neurobiological mechanisms underpinning positive and negative emotions will elucidate pathways of resilience to stress and disease and provide enhancement of animal and human welfare.
Perineuronal nets (PNNs) are extracellular matrix structures surrounding neurons which provide protection and influence synaptic plasticity; integral to learning and memory consolidation. Changes in PNN morphology are seen in models of stress.
This project will investigate perineuronal nets as a non-cellular mechanism of emotion and mood.