Ubiquitin signalling in human diseases
This honours project will investigate the effect of ubiquitin signalling on cell differentiation.
The ubiquitin signalling regulates cell differentiation, protein degradation and membrane trafficking. This project will investigate the subset of identified deubiquitinating enzymes and will determine their modulator effect on dopaminergic neuronal differentiation and signalling in different conditions.
You will express and deplete the enzyme targets for functional analyses.
This exciting project is based at the South Australian Health and Medical Research Institute (SAHMRI).
You will use human proteins associated with cancers, neurodevelopment and neurodegenerative diseases. The project will use range of biochemical and cell and molecular biological assays and cell culture suitable for students from molecular and biomedical sciences.
Supervisor
Associate Professor Pirjo Apaja
Contact: p.apaja@adelaide.edu.au
Research area: Molecular and biomedical sciences, Apaja Group
Recommended honours enrolment: Honours in Molecular and Biomedical Science