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Deciphering the catalytic potential & the electron transfer pathways of microorganisms

Electron transfer pathways

Honours project: Study new enzymes and the associated ferredoxins from bacteria found in interesting environments (or genes from metagenomes) or which carry out novel reactions.

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Identifying new drugs that kill parasites

Honours project: Work with a team of researchers who are identifying and characterising novel drugs that kill apicomplexan parasites.

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Directed evolution of proteins in vivo

Honours project: Use a new phage-based directed evolution approach to evolve proteins with properties to make them suitable for use in synthetic circuit applications, such as in vivo biosensing or construction of bistable switches.

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Synthetic phage therapy

Synthetic phage therapy

Honours project: Investigate the structural biology of bacteriophage proteins.

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Synthesis using Nature’s catalysts; enzymes

Stephen Bell Biocatalyst 2

Honours project: Projects in this area involve the isolation and study new enzymes from bacteria of interest or taking existing enzymes and adapting them for chemical synthesis.

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Understanding the mechanism of enzyme catalysed reactions of importance in drug metabolism

Stephen Bell - Mechanism of enzyme catalysed reactions of importance in drug metabolism

Honours project: Learn about the mechanism by which the major family of enzymes involved in drug metabolism catalyse oxidative transformations.

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Improving food safety using plasma sterilisation

Improving food safety using plasma sterilisation

Honours project: Investigate the use of a high energy form of matter (plasma) to improve food safety.

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Role of eEF2K & cancer cell migration & invasion

Cancer cells survive and gain the ability to spread under microenvironmental stress conditions through the inhibition of mTORC1 and subsequent activation of eEF2K

Honours project: Study cell signalling and gene regulation through the exploration of the role of eukaryotic elongation factor 2 kinase (eEF2K) and cancer cell migration and invasion.

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Group B Strep & oxidative stress

Dr Stephen Kidd

Honours project: Identify the response of Group B Streptococcus to relevant reactive oxygen and reactive nitrogen species.

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Staphylococcus aureus & lifestyle variations

Stephen Kidd Staph

Honours project: Conduct biomedical research into Staphylococcus aureus (Golden staph).

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