News: Honours projects - Chris Proud
Role of eEF2K & cancer cell migration & invasion
![Cancer cells survive and gain the ability to spread under microenvironmental stress conditions through the inhibition of mTORC1 and subsequent activation of eEF2K](/sites/default/files/styles/ua_landscape/public/media/images/2019-06/proud-figure1-cancer-cells-survive.png?h=d470be75&itok=uM8YIUca)
Honours project: Study cell signalling and gene regulation through the exploration of the role of eukaryotic elongation factor 2 kinase (eEF2K) and cancer cell migration and invasion.
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Systematic analysis of the eIF4E interactome
![Active mTORC1 phosphorylates 4E-BP, preventing 4E1 binding. (B) mTORC1 inhibition leads to 4E-BP hypophosphorylation; 4E-BP now binds 4E1 and blocks eIF4F](/sites/default/files/styles/ua_landscape/public/media/images/2019-06/proud-figure-active-mtorc1.png?h=cafa2d6d&itok=OA1E0VC5)
Honours project: Conduct a systematic analysis of the eIF4E interactome to understand the distinct functional roles of the three mammalian eIF4E proteins in translation initiation.
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Cellular-stress induced activation of non-TFEB regulated lysosomal genes
![Cellular stress-induced transactivation of autophagy and lysosomal genes. In normal conditions, transcription factor EB (TFEB) is kept in the cytoplasm in an inactive form.](/sites/default/files/styles/ua_landscape/public/media/images/2019-06/proud-figure-cellular-stress.png?h=5a854f77&itok=BsDzr49I)
Honours project: Investigate the role of the eIF2α/ATF4 pathway in stress-induced transcription of non-TFEB genes.
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Exploring the functions of MAPK-interacting kinases (MNKs) in metabolic disease
![MNKs play a key role in promoting adipocyte differentiation and this will be explored using the 3T3-L1 system](/sites/default/files/styles/ua_landscape/public/media/images/2019-06/proud-figure-mnks.png?h=29a9ff9b&itok=IYCRw7Qu)
Honours project: Explore the functions of MAPK-interacting kinases (MNKs) in metabolic disease at the South Australian Health and Medical Research Institute.
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