News: Honours projects - Molecular and biomedical science: Biochemistry

Structural study of misfolding proteins

An illustration of the neuropathology of Alzheimer's disease - BruceBlaus / CC BY-SA

Honours project: Investigate the structural characterisation of protein misfolding in amyloid diseases, such as Alzheimer’s and Parkinson’s.

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Saving megafauna from bacteria

A skeleton of a Marsupial Lion (Thylacoleo carnifex) in the Victoria Fossil Cave, Naracoorte Caves National Park Karora, Public domain

Honours projects: Identify and image biofilms that threaten the Naracoorte Caves National Park fossils.

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Retinal energy metabolism and links to eye disease

Honours project: Investigate retinal metabolism associated with eye disease.

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Making a bistable switch

Making a bistable switch

Honours project: This honours project involves the design, construction and testing of an activator based bistable switch.

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Role of HIFs in cancer

Decipher the specific roles of HIF1 and HIF2 in multiple myeloma.

Honours project: Decipher the specific roles of HIF1 and HIF2 in multiple myeloma.

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Directed evolution of proteins in vivo

Honours project: Use a new phage-based directed evolution approach to evolve proteins with properties to make them suitable for use in synthetic circuit applications, such as in vivo biosensing or construction of bistable switches.

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Synthetic phage therapy

Synthetic phage therapy

Honours project: Investigate the structural biology of bacteriophage proteins.

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Deciphering & exploiting bacterial cholesterol metabolism to combat disease

Deciphering & exploiting bacterial cholesterol metabolism to combat disease

Honours project: Address the fundamental science behind the use of the steroid cholesterol as a source of energy by bacteria.

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Role of eEF2K & cancer cell migration & invasion

Cancer cells survive and gain the ability to spread under microenvironmental stress conditions through the inhibition of mTORC1 and subsequent activation of eEF2K

Honours project: Study cell signalling and gene regulation through the exploration of the role of eukaryotic elongation factor 2 kinase (eEF2K) and cancer cell migration and invasion.

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Systematic analysis of the eIF4E interactome

Active mTORC1 phosphorylates 4E-BP, preventing 4E1 binding. (B) mTORC1 inhibition leads to 4E-BP hypophosphorylation; 4E-BP now binds 4E1 and blocks eIF4F

Honours project: Conduct a systematic analysis of the eIF4E interactome to understand the distinct functional roles of the three mammalian eIF4E proteins in translation initiation.

[Read more about Systematic analysis of the eIF4E interactome]

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